VDR is a gene which codes for a vitamin D receptor protein. This protein regulates calcium absorption and bone development. A variant of the gene called rs2228570 (FokI polymorphism), is associated with lower bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal virtual data rooms for business and temporal pattern of off- and on- occupancy of the VDRE by the two components, and is influenced by chromosomal locations and by binding preferences for specific hormones. Microarray studies of human cells reveal that over 100 genes contain a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) can serve as a repository of data and documents that are relevant to business, legal transactions, or procedures. Access to the data, downloading, and printing are all restricted. It makes use of a central server and an extranet connection, which is an Internet connection that has restricted access, which allows controlled log-on for set time periods during which users are able to browse the documents and data.
Investment bankers and companies involved in mergers and acquisitions are the most frequent users of VDRs. VDR. They require to share information in a transparent way with potential investors or buyers. The due diligence process may also require a huge amount of information. Life science companies also make use of VDRs for everything from clinical trials results to HIPAA documentation for compliance.
