Triple negative is essentially the most aggressive breast cancer subtype. In the metastatic scenario, median total survival is about 15 months, as in comparison with other organic subtypes that exceed 4 years . Nowadays, improvement in survival has been shown dramatically in the HER2 overexpressed subtype due to the incorporation of latest focused therapies, missing this benefit in superior triple unfavorable breast most cancers . Thus, new therapeutic methods are necessary in TNBC sufferers. For TMB calculation, SNVs detected by Mutect2 (3.8) were used. For neoantigen selection, SNVs referred to as by 2 or extra callers were thought of.
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